abstract：:Isovitexin exhibits potent antioxidant activities. In this study, the activity of nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW264.7 macrophages after incubation with isovitexin was investigated. Isovitexin was able to reduce the production of hydrogen peroxide induced by LPS in mouse macropha...

journal_title：Planta medica

authors： Lin CM,Huang ST,Liang YC,Lin MS,Shih CM,Chang YC,Chen TY,Chen CT

更新日期：2005-08-01 00:00:00

abstract：:This review describes the current status of the development of techniques combining liquid chromatography and nuclear magnetic resonance and their use in the context of natural products. HPLC-NMR methods have a rapidly growing impact on natural products research by enabling structure determination of natural products ...

journal_title：Planta medica

authors： Jaroszewski JW

更新日期：2005-08-01 00:00:00

abstract：:To assess possible herb-drug interactions, rutaecarpine (an herbal ingredient of Evodia rutaecarpa; 25 mg/kg/day, p. o.), the ethanol extract of Evodia rutaecarpa (1 g/kg/day, p. o.), and an herbal preparation of Evodia rutaecarpa (Wu-Chu-Yu-Tang; 1 g/kg/day) were individually pretreated daily for three consecutive da...

journal_title：Planta medica

authors： Tsai TH,Chang CH,Lin LC

更新日期：2005-07-01 00:00:00

abstract：:[6]-Gingerol potently inhibits peroxynitrite-induced oxidation and nitration reactions, but its mechanism of action is unclear. In order to discover the mechanism of inhibition, [6]-gingerol was reacted with peroxynitrite and the reaction mixture was analyzed using HPLC. The HPLC chromatogram showed one novel peak, in...

journal_title：Planta medica

authors： Ippoushi K,Ito H,Horie H,Azuma K

更新日期：2005-06-01 00:00:00

abstract：:The aim of this study was to investigate the protective effect of (S)-bakuchiol isolated from the seed of Psoralea corylifolia, on liver injury. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (CCl4) or D-galactosamine (D-GalN). Liver injury was induced by either...

journal_title：Planta medica

authors： Park EJ,Zhao YZ,Kim YC,Sohn DH

更新日期：2005-06-01 00:00:00

abstract：:Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investig...

journal_title：Planta medica

authors： Dudai N,Weinstein Y,Krup M,Rabinski T,Ofir R

更新日期：2005-05-01 00:00:00

abstract：:The present study is aimed at evaluating the effects of luteolin on the scratching behavior associated with an allergic cutaneous reaction in mice. Elicitation of passive cutaneous anaphylaxis, and intradermal injections of compound 48/80, histamine or serotonin induced scratching behavior in ICR mice. Models of irrit...

journal_title：Planta medica

authors： Baolin L,Weiwei W,Ning T

更新日期：2005-05-01 00:00:00

abstract：:The cardiovascular effects of intravenous (i.v.) treatment with the essential oil of Ocimum gratissimum (EOOG) and its main constituent, eugenol (Eug) were investigated in the experimental model of deoxycorticosterone acetate (DOCA-salt)-hypertensive rats. In both conscious DOCA-salt hypertensive rats and their uninep...

journal_title：Planta medica

authors： Interaminense LF,Leal-Cardoso JH,Magalhães PJ,Duarte GP,Lahlou S

更新日期：2005-04-01 00:00:00

abstract：:Propionibacterium acnes, an anaerobic pathogen, plays an important role in the pathogenesis of acne and seems to initiate the inflammatory process by producing proinflammatory cytokines. In order to demonstrate the anti-inflammatory effects and action mechanisms of magnolol and honokiol, several methods were employed....

journal_title：Planta medica

authors： Lee J,Jung E,Park J,Jung K,Lee S,Hong S,Park J,Park E,Kim J,Park S,Park D

更新日期：2005-04-01 00:00:00

abstract：:A new isoprenylated xanthone, cudrafrutixanthone A, was isolated from the roots of Cudrania fruticosa, together with 18 known compounds. Their structures were elucidated by spectroscopic methods. Most isoprenylated xanthones exhibited cytotoxicity against HCT-116, SMMC-7721, SGC-7901, and BGC-823 cell lines with IC (5...

journal_title：Planta medica

authors： Wang YH,Hou AJ,Zhu GF,Chen DF,Sun HD

更新日期：2005-03-01 00:00:00

abstract：:The effects of the essential oil of Mentha pulegium L. (EOMP), a plant commonly known as "pennyroyal" or "poejo" that is used in folk medicine as an abortifaceant, were assessed on the isolated rat myometrium. Myometrial strips were stimulated with 10 nM oxytocin or 10 microM PGF (2alpha). EOMP (10 - 300 microg/mL) co...

journal_title：Planta medica

authors： Soares PM,Assreuy AM,Souza EP,Lima RF,Silva TO,Fontenele SR,Criddle DN

更新日期：2005-03-01 00:00:00

abstract：:Scopoletin exhibited an immediate and dose-dependent hypouricemic effect after intraperitoneal administration (50, 100, 200 mg/kg) in hyperuricemic mice induced by potassium oxonate; however, it did not affect the serum uric acid level in normal mice at the tested doses. For exploring the involved mechanisms of action...

journal_title：Planta medica

authors： Ding Z,Dai Y,Wang Z

更新日期：2005-02-01 00:00:00

abstract：:Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a c...

journal_title：Planta medica

authors： Hsu YL,Kuo PL,Lin LT,Lin CC

更新日期：2005-02-01 00:00:00

abstract：:The therapeutic goal in liver fibrosis is the reversal of fibrosis and the selective clearance of activated hepatic stellate cells (HSCs) by inducing apoptosis. Over the past several years, we have screened for natural products that mediate apoptosis in activated HSCs. Among the candidate compounds, honokiol, isolated...

journal_title：Planta medica

authors： Park EJ,Zhao YZ,Kim YH,Lee BH,Sohn DH

更新日期：2005-01-01 00:00:00

abstract：:The mechanism of action, leakage of cytochrome c from mitochondria into cytosol, for the antineoplastic compound glyfoline was examined. Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC). A reverse ...

journal_title：Planta medica

authors： Su TL,Huang HM,Wang CK,Wu HC,Lin CT

更新日期：2005-01-01 00:00:00

abstract：:As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The struct...

journal_title：Planta medica

authors： Zhang Z,Li S,Zhang S,Liang C,Gorenstein D,Beasley RS

更新日期：2004-12-01 00:00:00

abstract：:In this study we investigated the effects of concomitant food intake on the bioavailability of distinct boswellic acids (BAs) from the test preparation BSE-018, a dry extract from Boswellia serrata gum resin. In a randomised, open, single-dose, two-way crossover study, healthy male subjects received three capsules of ...

journal_title：Planta medica

authors： Sterk V,Büchele B,Simmet T

更新日期：2004-12-01 00:00:00

abstract：:Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-tri...

journal_title：Planta medica

authors： Espindola LS,Vasconcelos Júnior JR,de Mesquita ML,Marquié P,de Paula JE,Mambu L,Santana JM

更新日期：2004-11-01 00:00:00

abstract：:Compelling evidence suggests that infiltrating CD4+ type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain...

journal_title：Planta medica

authors： Chang SL,Chang CL,Chiang YM,Hsieh RH,Tzeng CR,Wu TK,Sytwu HK,Shyur LF,Yang WC

更新日期：2004-11-01 00:00:00

abstract：:A mixture of cyanogenic glucosides epivolkenin and taraktophyllin, 1,4-dihydroxy-2-cyclopentenecarboxamide, and uridine were isolated from leaves of Lindackeria dentata (Flacourtiaceae). Another cyclopentanoid amide, (1 R,4 S,5 R)-1,4,5-trihydroxy-2-cyclopentenecarboxamide, was synthesized in two steps from gynocardin...

journal_title：Planta medica

authors： Jaroszewski JW,Ekpe P,Witt M

更新日期：2004-10-01 00:00:00

abstract：:The effects of gallic acid on the gene expressions of inducible nitric oxide synthase (iNOS) and the cytokines interleukin (IL)-1, IL-10, IL-12, IL-18, TNF-alpha, and interferon (IFN)-gamma were investigated by reverse-transcription polymerase chain reaction (RT-PCR). The experiments were performed in parallel in non-...

journal_title：Planta medica

authors： Radtke OA,Kiderlen AF,Kayser O,Kolodziej H

更新日期：2004-10-01 00:00:00

abstract：:In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...

journal_title：Planta medica

authors： Lee JB,Hayashi K,Maeda M,Hayashi T

更新日期：2004-09-01 00:00:00

abstract：:Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. Recently, rutaecarpine has been characterized to have an anti-inflammatory activity through cyclooxygenase-2 inhibition. In the present studies, the effects of rutaecarpine on liver cytochrome P450 s (P450s) and P450 s involved...

journal_title：Planta medica

authors： Lee SK,Kim NH,Lee J,Kim DH,Lee ES,Choi HG,Chang HW,Jahng Y,Jeong TC

更新日期：2004-08-01 00:00:00

abstract：:Bioactivity-guided fractionations for ACAT inhibitor led to the isolation of guineensine from the CHCl (3) extract of Piper longum. Its structure was identified by spectroscopic means (IR, UV, MS and NMR). Guineensine inhibited ACAT activity in a dose-dependent manner with an IC (50) value of 3.12 micro M. ...

journal_title：Planta medica

authors： Lee SW,Rho MC,Nam JY,Lim EH,Kwon OE,Kim YH,Lee HS,Kim YK

更新日期：2004-07-01 00:00:00

abstract：:Phytoestrogens are discussed as candidate substances to treat symptoms related to estrogen deficiency. In in vitro experiments, the naturally occurring flavonoid 6-(1,1-dimethylallyl)naringenin (6-DMAN) emerged as one of the most potent phytoestrogenic substances. 6-DMAN is not as well characterized as other flavonoid...

journal_title：Planta medica

authors： Zierau O,Geis RB,Tischer S,Schwab P,Metz P,Vollmer G

更新日期：2004-07-01 00:00:00

abstract：:A new acylated flavonoid, quercetin 3- O-alpha- L-(5"- O-acetyl)-arabinofuranoside ( 1), along with six known flavonoids ( 2 - 7) were isolated from the aerial parts of Rodgersia podophylla. The new flavonoid 1 exhibited 50.1 % hepatoprotective activity at a concentration of 100 microM, and the three known compounds 3...

journal_title：Planta medica

authors： Chin YW,Lim SW,Kim YC,Choi SZ,Lee KR,Kim J

更新日期：2004-06-01 00:00:00

abstract：:Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...

journal_title：Planta medica

authors： Laupattarakasem P,Houghton PJ,Hoult JR

更新日期：2004-06-01 00:00:00

abstract：:We have identified kamebakaurin as an inhibitor of NF-KB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-KB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expressi...

journal_title：Planta medica

authors： Lee JH,Choi JK,Noh MS,Hwang BY,Hong YS,Lee JJ

更新日期：2004-06-01 00:00:00

abstract：:From an extract of the whole plant of Ligularia virgaurea ssp. oligocephala, three new eremophilane sesquiterpene lactones, 10alpha-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6alpha,10alpha-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6beta,10beta-dihydroxyeremophila-7(11),8(9)-dien-12,8-olid...

journal_title：Planta medica

authors： Wu QX,Shi YP,Yang L

更新日期：2004-05-01 00:00:00

abstract：:Four new phenanthroindolizidine alkaloids, tylophoridicines C-F, together with three known ones, R-(+)-deoxytylophorinidine, tylophorinine and tylophorinidine, were isolated from the roots of Tylophora atrofolliculata. The structures were determined on the basis of spectral evidence. These alkaloids exhibited cytotoxi...

journal_title：Planta medica

authors： Huang X,Gao S,Fan L,Yu S,Liang X

更新日期：2004-05-01 00:00:00

abstract：:Lipophilic extracts of Isatis tinctoria L. exhibit significant activity against several clinically relevant targets of inflammation. The alkaloid tryptanthrin was identified as one of the active principles in woad and characterised as a potent dual inhibitor of COX-2 and 5-LOX. Here, the anti-inflammatory efficacy of ...

journal_title：Planta medica

authors： Heinemann C,Schliemann-Willers S,Oberthür C,Hamburger M,Elsner P

更新日期：2004-05-01 00:00:00

abstract：:Two new depsides as well as the known p-hydroxybenzoic acid and its methyl ester, protocatechuic acid, 2-(4-hydroxyphenyl)-ethanol, 2-(3,4-dihydroxyphenyl)-ethanol and the flavonoids kaempferol, quercetin, luteolin and hypolaetin and the glycosides 3- O-beta- D-glucopyranosylquercetin (isoquercitrine), 3- O-beta- D-gl...

journal_title：Planta medica

authors： Hillenbrand M,Zapp J,Becker H

更新日期：2004-04-01 00:00:00

abstract：:The acylphloroglucinol derivative hyperforin is a major constituent of St. John's wort extracts ( Hypericum perforatum L.), which has been demonstrated to contribute to the antidepressant action of this herbal drug. In previous investigations we observed that hyperforin causes a rapid stimulation of intracellular calc...

journal_title：Planta medica

authors： Schrattenholz A,Schroer K,Chatterjee SS,Koch E

更新日期：2004-04-01 00:00:00

abstract：:As an exploratory investigation of antimicrobial promoting compounds, 3- O-acyl-(-)-epicatechins and 3- O-acyl-(+)-catechins possessing various aromatic groups and aliphatic chains of varying length from C4 to C16 for increasing lipophilicity were synthesized and tested for antimicrobial activities against Gram-positi...

journal_title：Planta medica

authors： Park KD,Park YS,Cho SJ,Sun WS,Kim SH,Jung DH,Kim JH

更新日期：2004-03-01 00:00:00

abstract：:Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...

journal_title：Planta medica

authors： Lin RW,Tsai IL,Duh CY,Lee KH,Chen IS

更新日期：2004-03-01 00:00:00

abstract：:Five abietane diterpenes were isolated from a hexane extract obtained from the roots of Aegiphila lhotzkyana and identified as uncinatone, cyrtophyllone B, teunvicenone E, sugiol and 12,16-epoxy-11,14-dihydroxy-6-methoxy-17(15 - 16)- abeo-abieta-5,8, 11,13,15-pentaene-3,7-dione. The last compound has only been describ...

journal_title：Planta medica

authors： Costa-Lotufo LV,Silveira ER,Barros MC,Lima MA,De Moraes ME,De Moraes MO,Pessoa C

更新日期：2004-02-01 00:00:00

abstract：:Scutellariae Radix (SR), the root of Scutellaria baicalensis (Labiatae), is widely used in clinical Chinese medicine. In order to investigate the effect of SR on the absorption and disposition of cyclosporine, rats were administered with cyclosporine orally (in the form of the microemulsion Neoral and intravenously wi...

journal_title：Planta medica

authors： Lai MY,Hsiu SL,Hou YC,Tsai SY,Chao PD

更新日期：2004-02-01 00:00:00

abstract：:In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 ...

journal_title：Planta medica

authors： Nunome S,Ishiyama A,Kobayashi M,Otoguro K,Kiyohara H,Yamada H,Omura S

更新日期：2004-01-01 00:00:00

abstract：:In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibit...

journal_title：Planta medica

authors： Abad MJ,Bermejo P,Alvarez M,Guerra JA,Silván AM,Villar AM

更新日期：2004-01-01 00:00:00

abstract：:A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, st...

journal_title：Planta medica

authors： Frédérich M,Choi YH,Verpoorte R

更新日期：2003-12-01 00:00:00